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Louisville
21C Museum Hotel Louisville
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75 photos
21C Museum Hotel Louisville Exterior photo The photo shows a sunny street scene in a city, featuring a prominent golden statue of a muscular male figure, likely a depiction of the Greek god Hercules or a similar mythological character. The statue stands on a light-colored pedestal in the midd21C Museum Hotel Louisville Exterior photo This photo captures a fascinating juxtaposition of two very different elements: a striking piece of art and an elegant dining setting. **The Artwork:** Dominating the upper portion of the image is a large, vibrant, and incredibly detailed sculpture 21C Museum Hotel Louisville Exterior photo This is a well-lit, professional photograph taken inside what appears to be a high-end bar or liquor store. In the center of the image is a smiling young woman with medium-brown, shoulder-length hair. She is wearing a black, sheer-sleeved blouse and

21C Museum Hotel Louisville - 5-Star Luxury Hotel in Louisville

Book on our site
up to 10% cheaper
than Booking.com
Check rooms and rates
From$167 /night
Check-in
31May
Check-out
01May
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, 40202
-
Steps from the Waterfront Park
Great
8.8
9.3
/10
4.6
4.5
/5

Loved by 21C Museum Hotel Louisville guests

Unique museum
Friendly staff
Comfortable rooms
Delicious meals
Great cocktails
"The concept of hotel, excellent restuarant and gallery is amazing"
Karen from United States
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"This hotel has a contemporary art gallery in its lobby."
ChucoChica from United States
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"One of a kind experience with very interesting art all around and best bourbon tasting bar on Main street!."
Bart from United States
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"I loved staying in an art museum."
Scott from United States
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"We spent the evening exploring the art, including in the hallways, the elevators and the public bathrooms."
lovetravelfoodwine from United States
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Art & Museum

The hotel houses over 9,000 square feet of exhibition space for contemporary art installations throughout the property. Temporary art galleries rotate regularly, with works displayed in hallways, elevators, and even the lobby bathrooms. Guests can access the museum 24 hours a day, turning every walk into a gallery visit.

Dining & Bar

Proof on Main, the on-site restaurant, serves southern cuisine with a focus on locally sourced ingredients. The bourbon bar stocks rare and allocated selections alongside regular pours, and hosts regular events with local distillers and spirits. Drink vouchers for complimentary bourbon tastings are provided to guests at check-in.

Accommodations

Guest rooms include king deluxe and other categories with high ceilings, floor-to-ceiling windows, and artist-designed decor unique to each room. Each room comes with a 50-inch flat-screen cable TV, minibar, and a desk with laptop safe. The bathrooms offer bathrobes, hairdryers, and blacklight night lights that make white linens glow blue.

Wellness & Fitness

The hotel provides a 24-hour fitness center, a sauna, and a steam room for guest relaxation. Full-body massage, hammam, and yoga classes are offered in the spa and wellness center. Bicycle rentals are available to explore the downtown area on two wheels.

Location & Nearby Attractions

The hotel sits within walking distance of the Louisville Slugger Museum & Factory, Muhammad Ali Center, and Kentucky Museum of Art & Craft. It is located near historic Whiskey Row and one block from major distillery experiences such as Green River, Bardstown, and Michter's. A free electric ZeroBus provides easy transportation around downtown Louisville.

Highlights

Art: Over 9,000 sq ft of contemporary art exhibitions open 24/7

Dining: Proof on Main with southern cuisine and bourbon tastings

Wellness: Sauna, steam room, and 24-hour fitness center

Location: Walking distance to Museum Row and Whiskey Row

Pet policy: Pet-friendly accommodations with no size restrictions stated

Business: Customizable event spaces with dedicated staff

“This hotel truly embraces its identity as a museum, seamlessly integrating significant art installations throughout the property. While the diverse artwork can be a conversation starter, the comfortable rooms and attentive staff provide a solid foundation for a pleasant stay, complemented by the well-regarded on-site dining.”
Hotel logo
James DavidEditor-in-Chief at Hotels5s

Select your room type

21C Museum Hotel Louisville offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
    Room Balcony
    2 persons
    29 sq. feet
    1 King-size bed
    Air conditioning
    Balcony
    room details
    Deluxe King Room
    2 persons
    31 sq. feet
    1 King-size bed
    Air conditioning
    Heating
    room details
    Corner Suite
    2 persons
    61 sq. feet
    1 King-size bed
    Air conditioning
    Bathtub
    room details
Show all rooms

Price and Room Availability Calendar

Check availability and prices for your dates now!
May 2026 - May 2027
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Check-in/ Check-out

Facilities

21C Museum Hotel Louisville offers amenities for your comfortable stay and unforgettable experiences
Facilities: Perfect
9.0/10Review score

General

  • No smoking on site
  • Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
Show more

Dining Onsite

At 21C Museum Hotel Louisville, dining transforms into an artful experience at Proof on Main. This modern American eatery fuses local flavors with a contemporary twist, making it a vibrant spot for both casual meals and elaborate culinary events.
21C Museum Hotel Louisville Restaurant photo The photo shows a brightly colored, unique bedroom with a striking geometric ceiling. The ceiling is constructed from numerous triangular panels, each covered in a different vibrant fabric – blues, greens, reds, oranges, yellows, pinks, and purples.
21C Museum Hotel Louisville Restaurant photo The photo shows the interior of a restaurant with a whimsical and artistic decor. The walls are a mix of exposed brick and a large, colorful wallpaper depicting a vintage floral pattern. Numerous framed pictures and artwork of varying sizes and style
21C Museum Hotel Louisville Restaurant photo The photo shows a brightly lit dining area with a whimsical and eclectic decor. The walls are covered in a busy, patterned wallpaper featuring a mix of floral and figural designs in warm, muted tones. Numerous framed artworks of varying sizes and s

Proof on Main

American
Ambiance
Modern and inviting, set within the vibrant context of a contemporary art museum.
Key Offerings
Signature dishes highlight local ingredients, while events like the Fork & Bottle dinner series feature guest distillers and artisan spirits, complemented by unique experiences such as the annual Hog & Barrel dinner showcasing Pappy Van Winkle.
Reservation
Recommended for special events.
Hours vary.

21C Museum Hotel Louisville Location

700 West Main Street, Louisville, 40202
Explore Louisville
Explore Louisville
  • Top Attractions
  • Activities
  • Dining
  • Entertainment
Kentucky Science Center
2 minutes walking
Hands-on exhibits and IMAX films offer a fun learning experience for families and science enthusiasts of all ages.
Louisville Slugger Museum & Bat Factory
3 minutes walking
A national treasure showcasing America's baseball history, with guided tours and a chance to see bats being made.
Muhammad Ali Center
4 minutes walking
Celebrating the legacy of Muhammad Ali through interactive exhibits and inspiring messages of hope and social justice.
KFC Yum Center
9 minutes walking
Home to exciting sports events and concerts, this multipurpose arena offers an electric atmosphere year-round.
Discover the local attractions near 21C Museum Hotel Louisville
Seek out the nearby landmarks that create a unique cultural experience near 21C Museum Hotel Louisville.
Perfect for discovering the art of whiskey making: Michter's Fort Nelson Distillery
Great for enjoying a baseball game in a lively atmosphere: Louisville Slugger Field
Ideal for enjoying live music and dancing: Jimmy Can't Dance
Suited for appreciating stunning architecture and history: Cathedral of the Assumption
Well suited for attending various events and conventions: Kentucky International Convention Center
Best for exploring the legacy of a boxing legend and humanitarian: Muhammad Ali Center
Great for catching concerts and sporting events: KFC Yum Center
Ideal for engaging with local history and exhibitions: The Frazier History Museum
Waterfront Park
17 minutes walking
A beautiful park along the Ohio River, great for jogging, picnicking, or relaxing with stunning river views.
Angel's Envy Distillery
19 minutes walking
Guided tours include insights into whiskey-making and tastings, perfect for enthusiasts and thrill-seekers alike.
Proof On Main
1 minute walking
A vibrant atmosphere featuring local ingredients; the bourbon-infused dishes are a must-try for visitors.
Bristol Bar & Grille
2 minutes walking
Known for its diverse menu, cozy vibe, with options ranging from seafood to steaks; vegetarian choices available.
Discover dining options near 21C Museum Hotel Louisville
Enjoy a selection of nearby restaurants offering diverse dining experiences near 21C Museum Hotel Louisville.
Perfect for seafood lovers seeking a casual dining experience: Atlantic No. 5
Ideal for enjoying hearty comfort foods: Main Eatery
Best for fine dining with high-quality steaks: Morton's The Steakhouse
Great for indulging in creative burgers and mussel dishes: Mussel & Burger Bar
Well suited for tasting local brews and American cuisine: Bristol Bar & Grille
Suited for enjoying authentic Mexican flavors: Los Aztecas Mexican Restaurant
Ideal for fast and customizable meals: Subway
Great for savoring locally sourced coffee: Heine Brothers S. Fourth Street
Fourth Street Live!
10 minutes walking
A lively entertainment district offering live music, dining, and nightlife, perfect for evening outings with friends.
Old Forester Distilling
15 minutes walking
Experience bourbon distillation with tours followed by tastings, making it a great stop for all ages in a fun setting.
Getting around
  • City Centre
    Louisville 23 min  ·  1.2 mi
  • Airports
    Louisville (SDF) 18 min  ·  7.4 mi
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
Wireless internet is available in the entire hotel for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel

Reviews and Ratings

Feedback about 21C Museum Hotel Louisville from previous guests about their experience.
Review score
Based on 434 verified reviews
9.0 /10
Perfect
88 %
Recommend
Breakfast
2.5/10
Cleanliness
9.1/10
Comfort
9.3/10
Facilities
9.0/10
Free WiFi
10.0/10
Location
9.4/10
Paid Wi-Fi
7.5/10
Staff
9.0/10
Value for money
8.3/10
Pros
Museum concept
Comfortable beds
Clean rooms
Responsive staff
Cons
Room assignment issues
Booking perk discrepancies
Management response
Guest reviews
based on 1899 reviews
4.5/5
based on 188 reviews
8.8/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews
Show more reviews
FAQs
About 21C Museum Hotel Louisville
What are the check-in and check-out times at 21C Museum Hotel Louisville?
Check-in is at 16:00 and check-out is at 11:00.
How far is 21C Museum Hotel Louisville from Louisville International Airport?
The hotel is located 10 km from Louisville International Airport.
What amenities are available at 21C Museum Hotel Louisville?
The hotel offers a fitness center, spa and wellness facilities, valet parking, and a 24-hour reception.
What types of dining options are available at 21C Museum Hotel Louisville?
The on-site restaurant, Proof on Main, offers unique southern cuisine and there is a bar/lounge area for guests.
Which nearby attractions are within walking distance of 21C Museum Hotel Louisville?
Nearby attractions include the Muhammad Ali Center (0.5 km), Louisville Slugger Museum (0.5 km), and the Kentucky Museum of Art & Craft (1 km).
What are the room amenities at 21C Museum Hotel Louisville?
Rooms include free Wi-Fi, a 50-inch flat-screen cable TV, a minibar, and air conditioning.
Is gluten-free or vegetarian dining available at 21C Museum Hotel Louisville?
The on-site restaurant offers gluten-free and vegetarian options.
What fitness and wellness facilities are offered at 21C Museum Hotel Louisville?
The hotel features a fitness center, spa with massage services, sauna, and yoga classes.
Does 21C Museum Hotel Louisville offer business services?
The hotel provides a business center, meeting rooms, and conference facilities for guests.
What are the transportation options available near 21C Museum Hotel Louisville?
Guests can access the free electric ZeroBus nearby, which provides routes to major downtown sites.
What kind of art experiences can guests expect at 21C Museum Hotel Louisville?
The hotel features contemporary art installations and exhibitions throughout its public spaces.

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Check-in
31May
Check-out
01May
Rooms and Guests2 Guests, 1 Room
  • Overview
  • Rooms
  • Price calendar
  • Facilities
  • Location
  • Reviews